Takahashi has appeared as the character "Takashi" in Justin Lin's directorial debut, Better Luck Tomorrow (2002). He also appeared in the film Memoirs of a Geisha (2005) as a Rickshaw Runner, and in Lane Nishikawa's film Only the Brave (2006) as one of the 442 2nd Squad Soldiers. Takahashi has additionally appeared as the male nurse character "Lee" in Peyton Reed's Yes Man opposite Jim Carrey. In 2013, Takahashi appeared as "Troy" in Rob Meltzer's Welcome to the Jungle (2013) opposite Jean-Claude Van Damme. In 2015, Takahashi appeared as Endo/Rambis (named after the coach Kurt Rambis), one of Josh Gad's character's "fake groomsmen" in Jeremy Garelick's The Wedding Ringer, starring Kevin Hart and Josh Gad.
Takahashi has appeared in a number of TV series, including Asia Street Comedy (2004-2005) (various characters), Reno 911! (as a Thai Delivery Man and a Storeowner), The Bill Engvall Show (2009) (as a Driver), Whacked (as a Korean Shopkeeper), Traffic Light (as a Nerdy Dad), Mr. Sunshine (as Jerry), ACME Saturday Night (as various characters), Community (as the Math Club Leader in the episode "A Fistful of Paintballs" Dir. Joe Russo), The Mentalist (as Tai Nguyen), Ben and Kate (as Shawn), Sullivan & Son (as Dr. Park), The Big Bang Theory (as a Scientist), The Millers (as Kevin), Conan (as various characters) and Dog Park (as Neal).
In addition to Better Luck Tomorrow, Takahashi has appeared in independent films such as Kiyong Kim's Ku Klux Korena (2007) (as Jin), Teruhisa Yoshida's Robert Hearts Miss Ing (2008), Tom Huang's Why Am I Doing This? (2009)(as Sung), James Huang's Starting From Scratch (2013) (as Jim), Peter O'Melia's The Grounds (2014) (as Applicant #4), and as Aaron, a fictionalized version of himself, in Awesome Asian Bad Guys (2013-2014), directed by Patrick Epino and Stephen Dypiangco.
Takahashi has appeared in over 45 national ad campaigns for brands such as Snapple, the NFL, Esurance, McDonald's, and Amp'd Mobile (where he plays a worker that raps the song "U and Dat" (featuring T-Pain and Kandi Girl) out loud in a bathroom before another employee notice him). Takahashi also provides the voice of "Paul Tard" in the videogame Slumber Party Slaughterhouse: The Game (2008).
Takahashi has also appeared in various short films such as Mike Nojun Park's Re: Your Balls (2009) (as Matt), James Huang's Represent (2010) (as Aaron), and Roman Cortez's My Best Friend Bigfoot Ep.1 & 2. (2010) (as Scott).
