After studying screenwriting at La Fémis, Winocour made three short films and wrote the script for Vladimir Perisic's film Ordinary People (released in 2009).
Winocour's first feature film, Augustine, based on the relationship between Professor Charcot and his patient Augustine, was presented at the Cannes Film Festival in 2012 as part of the Critics' Week. Her second directorial film Maryland was selected to be screened in the Un Certain Regard section at the 2015 Cannes Film Festival.
Winocour also co-wrote the film Mustang with Deniz Gamze Ergüven. It was screened in the Directors' Fortnight section at the 2015 Cannes Film Festival The film was selected as the French entry for the Best Foreign Language Film at the 88th Academy Awards.
She was named as a member of the jury of the International Critics' Week section of the 2016 Cannes Film Festival.
