Seales's first film was a minor role as Katy in the 1993 movie Cop and a Half. The next year Seales was featured on the Nickelodeon sitcom My Brother and Me (1994) as Deonne Wilburn. In 2002 she appeared on Russell Simmons' Def Poetry Jam. Seales became publicly known as "VJ Amanda Diva" on MTV2 Sucker Free Countdown on Sundays. In 2016 she appeared in a recurring role on the HBO series Insecure, as Tiffany DuBois. Also in 2016, Seales began hosting her own show on truTV called Greatest Ever.
In 2007, Seales replaced Natalie Stewart of the musical duo Floetry on tour with Marsha Ambrosius, and in December of that same year Seales (as Amanda Diva) released her first extended play (EP) Life Experience. In 2008, she was featured on the song "Manwomanboogie" on Q-Tip's Grammy-nominated album The Renaissance. On March 3, 2009, Seales released Spandex, Rhymes & Soul.
In 2011, she changed her professional name back to her birth name.
In 2017, Seales teamed up with Truth, to start an anti-smoking campaign.
