In 2011, Landecker was a regular cast member of The Paul Reiser Show on NBC, playing Paul Reiser's wife, Claire. On television, she has guest starred on Law & Order: Special Victims Unit, Law & Order: Criminal Intent, NCIS, Curb Your Enthusiasm (where she met and started to date Larry David), Revenge, and many more series. She has also appeared in a number of Off-Broadway theatrical productions, including Bug. In 2013, Landecker co-starred in films All Is Bright, Clear History and Enough Said. In 2014, she was cast alongside Jeffrey Tambor and Judith Light in the Amazon Studios comedy-drama series, Transparent. She co-starred in the Michael Bay-produced time travel thriller Project Almanac, which was released in January 2015.
Landecker and her Transparent co-star Bradley Whitford began dating in early 2015.
