Anna Morandi was born in 1714 in Bologna, Italy. She was raised in a traditional home where marriage, children, and a domestic lifestyle were natural choices for women. In 1736, she was married to her childhood sweetheart, Giovanni Manzolini, a professor of anatomy at the University of Bologna. She was 20, and he was 24 years old. After five years of marriage, she was the mother of six children. In 1755, her husband died, and she was left with very slender means of support. She received tempting offers from other universities, but she preferred to remain in her native city, Bologna. She closed a laborious and honored life in the city in 1774, at the age of 60 years.