Aparna Brielle was born in Clackamas, Oregon to Partha Rajagopal and Girija Parthasarathy and was raised in Portland, Oregon. She has one younger brother, Vijay. As a child, she attended Valley Catholic School (then known as St. Mary of the Valley) in Beaverton, Oregon. At the age of nine, Brielle was amongst the youngest Bharatanatyam Dancers in the world to graduate in an Arangetram performance after a mere three years of training. She attended the Arts & Communications High School, appearing in performances such as their fall 2011 production of Godspell, still performing as Aparna Parthasarathy. Brielle then attended Linfield College, where she majored in marketing.
In 2014, Brielle made her television debut on NBC's supernatural drama Grimm. In 2015, she appeared in TNT's The Librarians and in 2016, she appeared in Fox's short-lived Cooper Barrett's Guide to Surviving Life.
In 2017, Brielle was cast as Sarika, "a career-driven student who’s constantly trying to do everything right and climb the ladder" in the NBC comedy A.P. Bio, which premiered in 2018.
