Weitzman was born and raised in Los Angeles, California. He is a regular performer at the Upright Citizens Brigade Theater in Los Angeles. He has appeared in television and film projects such as Burning Love, The Sarah Silverman Program, Childrens Hospital, Role Models, School for Scoundrels, Love, and Oceans 13 amongst other film and television programs. He was also on the short-lived MTV show, Zach Stone Is Gonna Be Famous, as the title character's best friend. He currently co-stars as the servant Garfield in the Comedy Central show Another Period, as Jeff in Silicon Valley (TV series) & Netflix's Love (TV series). Weitzman was awarded the Heart of a Chompian Award on the March 30, 2017 episode of Feral Audio's Doughboys podcast.
