Karkanis co-starred in several horror films, including Saw IV (2007), Repo! The Genetic Opera (2008), Saw VI (2009), Survival of the Dead (2009), and The Barrens (2012). She also appeared in direct-to-video action films The Art of War II: Betrayal (2008), and Sacrifice (2011). On television, she was a regular cast member in the first season of Canadian teen drama The Best Years in 2007, in The Border from 2008 to 2010, and in the short-lived comedy series Almost Heroes in 2011. She also had a recurring role in Lost Girl from 2011 to 2012.