During the 1980s, Moreno was a favorite of Pulitzer Prize-winning Playwright Beth Henley. Moreno performed in at least four premieres of Henley's plays. Henley created several roles specifically for Moreno: "Popeye" in The Miss Firecracker Contest, some dialogue of which was based on a true story told to the Playwright by Moreno, and as "Lacey Rollins" in the two-act play The Lucky Spot. Moreno performed in Firecracker at the Victory Theater in Burbank, California, in 1980, and in Lucky Spot off-Broadway at the Manhattan Theatre Club in 1987.
Moreno also appeared in Henley's 1982 Broadway premiere at the Eugene O'Neill Theater of The Wake of Jamey Foster as "Katty Foster", directed by Ulu Grosbard, and in the 1989 world premiere of Abundance, as "Macon" at the South Coast Repertory in Costa Mesa, California.
Soon after Moreno arrived in Hollywood, California, to pursue her acting career, she met Director Robert Altman, and landed roles in three of his films: 3 Women, A Wedding, and A Perfect Couple. She appeared in many other films, including Mommie Dearest, Swing Shift, Oh, God! You Devil, Nobody's Fool, Men Don't Leave, Clear and Present Danger and Grosse Pointe Blank. Moreno was a regular on the long-running ABC sitcom Perfect Strangers from 1986 to 1992. Her work on television includes appearances in television movies, such as Crazy From the Heart and Death Benefit, the miniseries Tales of the City, and in numerous sitcoms and dramatic series, including The Golden Girls, Family Ties, Valerie and Melrose Place. Moreno played Benny Lopez, George's mother, Benny Lopez, on George Lopez from 2002–07.
Since the early 1990s, Moreno has served as an acting coach and advisor on numerous films, such as Jerry Maguire, Rush Hour 2, Almost Famous, Parent Trap, The Family Man, Crossroads and 17 Again. She also appeared on Disney's Wizards of Waverly Place and Fairly Legal on USA Network.
