On July 31, 2016, the Indians traded Heller along with Clint Frazier, Justus Sheffield and J. P. Feyereisen to the New York Yankees for Andrew Miller. The Yankees promoted Heller to the major leagues on August 11. He was demoted without making an appearance. The Yankees promoted him again on August 23. Heller made his major league debut on August 26, 2016 against the Baltimore Orioles, pitching a scoreless 8th inning.