Foxworth played the murderer, an Army colonel, in Grand Deceptions, a 1989 episode of the TV series Columbo. He has also guest-starred in Hawaii Five-O, Password Plus, Murder She Wrote, seaQuest DSV, Star Trek: Deep Space Nine, The Outer Limits, Star Trek: Enterprise, Stargate SG-1, and Babylon 5. He has done voice acting as the corrupt Professor Hamilton on Justice League Unlimited. He also voiced the autobot Ratchet, in the film version of Transformers and its sequels.