He has frequently been identified with the New Queer Cinema movement that emerged in the 1990s, although at the height of that movement's prominence, he rejected the association on the grounds that he felt more personally aligned with the queercore movement. The queercore movement was born in the 1980s and LaBruce was one of the fathers. Noted as the avant-garde and unapologetic gay answer to the punk movement, queercore expressed the very same discontent with society as the punks were stating.
His movie, Otto; or Up with Dead People debuted at the 2008 Sundance Film Festival. L.A. Zombie was banned from the Melbourne International Film Festival in 2010 because, in the opinion of Australian censors, it would have been refused classification. However, the film was subsequently able to screen at OutTakes, a New Zealand lesbian and gay international film festival, in May 2011.
In March 2011, LaBruce directed a performance of Arnold Schoenberg's opera Pierrot Lunaire at the Hebbel am Ufer Theatre in Berlin. This iteration of the opera included gender diversity, castration scenes and dildos, as well as portraying Pierrot as a transgender man. He subsequently also filmed this adaptation as the 2014 theatrical film Pierrot Lunaire.
Beginning with Gerontophilia in 2013, LaBruce dropped some of the more sexually explicit aspects of his filmmaking style. He retained his traditional interest in exploring sexual taboos, dramatizing an intergenerational relationship between a young man and a senior citizen, but opted to do so within a film that would be more palatable to a mainstream audience.
