Lowell has been married three times. Her first husband was fashion Photographer John Stember, to whom she was married from 1984 to 1988.
She was married to actor Griffin Dunne from 1989 to 1995 and has a daughter, Hannah, from that marriage.
She left acting after the mid-2000s. In 2012, Lowell lent her likeness and voice while reprising her Licence to Kill role in the video game 007 Legends.
Lowell married actor Richard Gere in November 2002, following the birth of their child Homer James Jigme Gere, who was born in February 2000.
In September 2013, the two separated after 11 years of marriage. The couple spent three years in highly contested divorce proceedings in Manhattan Supreme Court. The case was settled in October 2016.
