Locatell first movie role was in the 1973 film Coffy. She also appeared in the Burt Reynolds films Paternity, Best Friends and Sharky's Machine. She also has made guest appearances on many television shows, including Bonanza, M*A*S*H, ER, The Practice, 7th Heaven, Touched by an Angel, Without a Trace, and Grey's Anatomy. In 2014 she appeared in the sixth episode of the fourth season of Shonda Rhimes' political drama series, Scandal as former First Lady Bitsy Cooper.