Otis began modeling at age 16. Discovered in San Francisco, she was initially signed to Elite Model Management by John Casablancas. She first achieved fame while working for Elite in Paris, when she appeared on the cover of French Elle in April 1986. Over the next several years, she appeared on covers in the American and foreign editions of Vogue, Harper's Bazaar, Cosmopolitan, Allure, Mirabella, and Marie Claire.