Pounder started her professional career in New York City theater, where she appeared in The Mighty Gents, by Playwright Richard Wesley, and Open Admissions on Broadway. She moved to Los Angeles in 1982. Pounder starred in the film Bagdad Café, and has made smaller appearances in many other successful films. She has focused primarily on her television career. In the early 1980s, Pounder first appeared in guest roles on Hill Street Blues, and then on several popular shows (The Cosby Show, RoboCop 3, L.A. Law, The X-Files, Living Single, and Quantum Leap) before landing a long-running recurring role as Dr. Angela Hicks on ER, from 1994 to 1997. In the midst of this she co-starred in the Tales From the Crypt feature film Demon Knight (1995). She then returned to guest appearances on other shows, including The Practice, Law & Order: Special Victims Unit, Millennium, The West Wing (where she was considered for the role of C. J. Cregg), and the short-lived sitcom Women in Prison.