McBride was born in Chicago, Illinois, from which his nickname, Chi, derives. He was raised in the Seventh-day Adventist religion and attended Shiloh Academy, now known as Chicago SDA Academy, a Seventh-day Adventist school. He graduated from high school at the age of 16. McBride originally planned to pursue a career in music. After studying several instruments and singing with gospel choirs in his native Chicago, he relocated to Atlanta, Georgia in 1986 to work for AT&T as a billing clerk.
In 1998, he was a co-star of Mercury Rising, alongside Bruce Willis. He was later given the role of Principal Steven Harper on the series Boston Public. Much of McBride's work sees him playing right-hand man to the hero, as in the films Mercury Rising and The Terminal. He is notable for his television roles on Boston Public, The John Larroquette Show, House, The Secret Diary of Desmond Pfeiffer, Killer Instinct and Pushing Daisies.
He starred in Human Target as Winston, Business partner of Christopher Chance (the protagonist). The show premiered on January 17, 2010, on the Fox Broadcasting Company.
