In 2009, Cole played Dr. Sarah King in Poirot: Appointment with Death, and was cast in the lead role of Maggie Hill, a brilliant surgeon who endures adult-onset schizophrenia, in a pilot for Fox. She also starred in the films Surviving Evil (2009) alongside Natalie Mendoza and Billy Zane, and Doghouse (2009), with Danny Dyer and Billy Murray. Cole stars in the upcoming noir science fiction action thriller film The Scribbler which is directed by Jake West.