Harnos portrayed Jennifer Greene, the first wife of main character Mark Greene on ER (1994–2002), Josie Ray in Remembering Sex (1998), Dotty from The Girl Gets Moe (1997), Rimmer in the action-horror film Hellraiser: Bloodline (1996), Kaye Faulkner in Dazed and Confused (1993), Linda Wyatt in Judgement Night (1993), Sarah Hughes in Cold Dog Soup (1990), and Sid in Denial (1990).