Sapani appeared in Danny Boyle's film Trance. His stage credits include August Wilson's Joe Turner's Come and Gone and Radio Golf, Errol John's Caribbean classic Moon on a Rainbow Shawl and The National Theatre production of Euripides' Medea. He has also acted in the 2013 Indian action film, Singam II as an international drug lord. His TV roles include appearances on Misfits, Ultimate Force and Blackout, while his television guest appearances include Judge John Deed and the Doctor Who episode "A Good Man Goes to War." as Colonel Manton. For the first two seasons, Sapani played the role of Sembene in Showtime's Penny Dreadful.