After appearing in Playboy magazine as Playmate of the Month July 1997, she appeared in several Playboy videos. Her Playmate pictorial was photographed by Richard Fegley.
Duplaix became a regular cast member on the American television soap opera Passions in 2004, playing Valerie Davis until 2008. In January 2009, Duplaix served as a host of the Playboy TV game show Show Us Your Wits. She next began appearing as Rachel Gannon on the ABC soap opera One Life to Live on April 7, 2009.
Duplaix was previously married to Ron Samuel, with whom she has three sons. On June 28, 2014, she married Grady Heiberg. In September 2015, she and Heiberg welcomed a daughter.
