Some of the best known films he has written include the sci-fi adventure films Jurassic Park (1993), The Lost World: Jurassic Park (1997), and Indiana Jones and the Kingdom of the Crystal Skull (2008); the action spy films Mission: Impossible (1996) and Jack Ryan: Shadow Recruit (2014); the superhero film Spider-Man (2002); the sci-fi disaster film War of the Worlds (2005) and the mystery thriller Angels & Demons (2009). Koepp has directed six films over the course of his career: The Trigger Effect (1996), Stir of Echoes (1999), Secret Window (2004), Ghost Town (2008), Premium Rush (2012), and Mortdecai (2015).
Koepp has also worked in television, creating the 2002 series Hack starring David Morse.
Koepp was reportedly paid $4,000,000 for his Panic Room screenplay. He wrote the screenplay for Indiana Jones and the Kingdom of the Crystal Skull and co-wrote and directed 2008's Ghost Town starring Ricky Gervais and Greg Kinnear.
On July 10, 2013, Lionsgate was reported to have acquired the comedic crime novel The Great Mortdecai Moustache Mystery, written by Kyril Bonfiglioli. Koepp directed the film, titled Mortdecai, from a script by Eric Aronson; Johnny Depp played the lead role of Charlie Mortdecai, and the film also featured Gwyneth Paltrow, Ewan McGregor, and Paul Bettany. Koepp adapted the Marcus Sakey novel Brilliance, which will star Will Smith and Noomi Rapace.
On March 15, 2016, the Walt Disney Company announced a fifth installment of the Indiana Jones saga, with Koepp as its Screenwriter.
