Pasquesi has performed at The Second City, iO Theater, Improv Institute, and Annoyance Theatre, and studied under Del Close in the early 80s and became part of the first iO Harold team "Baron's Barracudas". He appeared in four mainstage revues at Second City as well as in plays at the Steppenwolf Theatre and the Goodman Theatre. Since 2002, he has been performing with T. J. Jagodowski in "TJ and Dave".
The 2009 South by Southwest Film festival included the documentary Trust Us, This is All Made Up directed by Alex Karpovsky, which chronicles a "T.J. and Dave" performance. In 2009, he played a supporting role in the Harold Ramis film Year One as the Prime Minister of Sodom.
