Pressman is an American human rights Lawyer and former aide to United States Secretary of State Madeleine K. Albright. He has advised a number of highly visible individuals on foreign policy and related advocacy strategies. In 2008 Los Angeles Times referred to him as George Clooney's "consigliere." With George Clooney, Brad Pitt, Matt Damon, Don Cheadle, and Jerry Weintraub, Pressman co-founded Not On Our Watch Project, a leading advocacy and grant-making organization focused on raising awareness about mass-atrocities.