Farentino began her acting career in 1982 when she was cast in the TV series Capitol. She has since appeared in over fifty movies and TV shows, including Hooperman (1987-1989) and Son of the Pink Panther (1993). Perhaps her most famous lead role was as Devon Adair in NBC's SciFi series Earth 2, the first female commander depicted in science fiction.
Over the span of four decades, she has guest starred in many television programs, including NYPD Blue (1994), the revival of The Outer Limits (1996), JAG (2002), CSI: Miami (2003), and Hawaii Five-0 (2011). Her most recent roles include as Isabelle Matia-Paris in the ABC series Wildfire and Beverly Barlowe in the Syfy Channel series Eureka.
She was chosen as one of People Magazine's "50 Most Beautiful People in the World" in 1995, while pregnant with daughter Sophie.
