Matthew Sanderson was born with his twin brother Michael to Tom and Patty Sanderson. He also has a sister, Heather. He attended Manatee High School before his family moved to North Carolina, where he graduated from South View High School in 2003. Sanderson started performing in drag while still a teenager in Florida. His drag mother was Florida performer Mizz Kori, who first put Detox into drag in an Orlando nightclub.
In 2009, Sanderson was in a car accident that required his forehead to be reconstructed.
In 2011, Detox acted in Showgirls in Drag, a live adaptation of Showgirls. The production was directed by Stephen Guarino and played at the Dragonfly nightclub in Hollywood.
In November 2012, Logo announced that Detox was among 14 drag queens who would be competing on the fifth season of RuPaul's Drag Race. Detox won the children's TV show-themed main challenge in the episode "Draggle Rock." As part of the show, Detox sang on the "We Are the World"-inspired song "Can I Get an Amen?" The song's proceeds helped benefit the Los Angeles Gay and Lesbian Center. Detox finished the season in 4th place.
In June 2016, Detox was announced as one of the cast members on the second season of RuPaul's All Stars Drag Race, where she was a Runner up along with Katya Zamolodchikova.
In 2017, Detox appeared in the film Cherry Pop, directed by Assaad Yacoub, alongside Drag Race alumni Tempest DuJour and season 8 winner Bob the Drag Queen, as well as drag queen Mayhem Miller.
