In 2000, Manoff appeared in the TV movie The Lost Child starring Mercedes Ruehl. Just a few months later in 2001, Manoff returned to film work by starring in The Amati Girls, the sole movie released theatrically in which her mother and she have appeared together. The film also featured Mercedes Ruehl, Sean Young, and Lily Knight. Manoff appeared in a second 2001 movie, Zigs, starring Beverly Hills, 90210's Jason Priestley. From 2001 to 2002, Manoff co-starred in the cable television series State of Grace. In 2003, Manoff played Aunt Marla in A Carol Christmas, a variation on Charles Dickens' classic story.