Diva Zappa's first film appearance was in the 1998 film Anarchy TV, along with her older siblings. Since then, she has also appeared in Children of the Corn V: Fields of Terror (1998), National Lampoon's Pledge This! (2006), as well as various TV shows including Felicity, Brothers & Sisters, and The Mighty Boosh.
In 1999, Diva Zappa released a comedy single called "When the Ball Drops" about her "hunt for someone to make out with on the Millennium". Tipper Gore played drums on the recording and Kristin Gore sang backup vocals.
Since 2002, Diva Zappa has run her own website/business called "Hand Made Beauty" where she sells her own self-designed and made clothing. The clothing is primarily knitted or crocheted, and consists of hats, ponchos and skirts. A percentage of all sales are donated to the Creative Visions Foundation. She was initially taught how to knit by Actress Laurie Metcalf. She does not plan her work, preferring to work in a spontaneous manner. In 2011, Zappa had her first UK show of "contemporary knitwear art and couture canvases" with an exhibition titled "Bruce" at the Maison Bertaux Gallery in Soho. The exhibition featured an embroidered photograph of her brother Dweezil playing guitar.
On October 29, 2013, she appeared in the UK premiere of her late father's orchestral work 200 Motels at the Royal Festival Hall, London, playing the role of Groupie 2 (Lucy).
Following the death of Zappa's mother, Gail, in October 2015, it was revealed that Diva and her brother Ahmet were given control of the Zappa Family Trust with shares of 30% each, while her siblings Moon and Dweezil were given smaller shares of 20% each. As beneficiaries only, Moon and Dweezil will not see any money from the trust until it is profitable—in 2016, it was "millions of dollars in debt"—and must seek permission from Ahmet, the trustee, to make money off of their father's music or merchandise bearing his name. The uneven divide of the trust has resulted in several conflicts between Zappa's children, including a feud between Dweezil and Ahmet over Dweezil's use of his father's music in live performances. In a 2016 interview with the Los Angeles Times, Diva Zappa said her primary role in the trust is to be present when her father's work is highlighted.
