After working in a number of plays, television episodes and commercials, Matheson was signed to join the cast of the Land of the Giants. He married co-star Deanna Lund in 1970, but they were divorced in the late 1970s. In 1976, he played the role of wealthy industrialist, Cameron Faulker, who married Lesley Williams (Denise Alexander) on General Hospital. His mistress, Peggy Lowell, was played by Lund. The Cameron character was later murdered. In 1984, Matheson had a regular role in Falcon Crest. He played Richard Channing's henchman for a season. He also appeared briefly in Dynasty.