From 1996 to 1999, Berrington starred alongside Emma Wray and Tony Robinson in the ITV comedy-drama 'My Wonderful Life'. In 1999, she played Marie Antoinette in Let Them Eat Cake, starring Dawn French and Jennifer Saunders. In cinema, Berrington has featured in many popular films such as The Little Vampire and, more recently, Nanny McPhee with Emma Thompson and In Bruges alongside Colin Farrell, Brendan Gleeson and Ralph Fiennes. In 2008 and 2009, a she played Mel in Moving Wallpaper. She was in the 2008 Poirot episode "Cat Among the Pigeons". Berrington also featured in the 1993 Mike Leigh film Naked. She also had a role in Leigh's 1996 drama film Secrets & Lies, starring Brenda Blethyn, Marianne Jean-Baptiste and Timothy Spall.