Gupta participated in Femina Miss India in 2007, where she won Miss Photogenic and came 3rd to go on to compete in Miss India International. She featured in the Kingfisher Calendar in 2010.
In 2014, Esha was seen in Sajid Khan's Comic Caper Humshakals alongside Saif Ali Khan, Ritesh Deshmukh, Ram Kapoor, Bipasha Basu and Tamannaah. Box Office India declared it a "disaster". She was ranked at 8th position for Times '50 most desirable Women of 2013.
