Her first movie was Along the Navajo Trail. Although it made her career take a better turn, Rodriguez did not enjoy making the movie, reportedly saying "Everyone treats me like a kid. I am a mother." Soon after this, she starred with western favorites Roy Rogers and Dale Evans in Twilight in the Sierras in 1950 and In Old Amarillo with Rogers. She concluded her career with Republic in 1952, and her last film was 1966's Jesse James Meets Frankenstein's Daughter. In 1959, she appeared in Rio Bravo.