She began modeling at age 19. Over the years, she has appeared in advertisements for Guess?, Cartier, Christian Dior, Revlon, Lord & Taylor, and Samsung. In 1988, she first appeared in the Sports Illustrated swimsuit issue. She was featured again in 1989, 1990, and 1993. In 1994, she was named one of the "50 most beautiful people" by People. In 1999, she was one of the candidates to become the official model for the French national symbol Marianne but ultimately lost to Laetitia Casta.
In 1994 she earned her first film role in the French comedy film Grosse Fatigue. In 2001 she portrayed a model for Gaultier in the Gabriel Aghion comedy Absolutely Fabulous and in 2007 she earned her first lead role in the horror film Frontière(s).
She was married to singer David Hallyday from September 1989 to 2000. The couple had two children: Emma and llona. She was also married to French TV and radio host Arthur from February 2004 to April 2008. Lefébure also has a son, Giuliano, born on 29 November 2010, with her partner Pascal, a restaurateur.
In 2012, She was one of the contestants during the Third season of Danse avec les stars.
