Scott was regular cast member in the short-lived ABC sitcom The Geena Davis Show (2000-2001) playing Geena Davis' housekeeper, Gladys. She also had the recurring roles on City Guys (1998-2001), short-lived The Help (2004) as Doris, and Hart of Dixie (2011-2015) as Delma Warner. In film, she has appeared in Boyz n the Hood (1991), The Kid (2000), You Got Served (2004), Dreamgirls (2006), Gangster Squad (2013), and The Birth of a Nation (2016).
