Amurri Martino had a role in the 2002 film The Banger Sisters, in which her mother starred, with Amurri Martino playing the daughter of her mother's character. She guest-starred, along with her mother, on an episode of Friends in Season 7 Episode 15 ("The One with Joey's New Brain") in which she is slapped by Sarandon. In 2004, she appeared in Saved!. She guest-hosted Attack of the Show with Kevin Pereira. She had a role in the third season of the Showtime series Californication, where she played Jackie, a stripper, student and love interest of central character Hank Moody. Amurri Martino played the leading role in the 2008 film Middle of Nowhere.