Jonigkeit was raised in Bucks County, Pennsylvania and graduated from Neshaminy High School in 2001. He got accepted into Temple University with a baseball scholarship but after being sidelined with tendonitis, he started pursuing theater.
After working in the theater community in Philadelphia, Jonigkeit was picked up by agency in New York. He got his break by starring in 2011 Broadway play "High" which eventually led him to star in Broadway play "The Snow Geese" alongside Mary-Louise Parker in 2013.
In 2014, Jonigkeit made his big-screen debut in X-Men: Days of Future Past playing comic book villain Toad.
In 2015, he starred alongside Kurt Russell in western Bone Tomahawk as Deputy Nick. In the same year he was cast to play Captain Chesterfield in Discovery Canada's series Frontier.
In 2013 Jonigkeit started dating Zosia Mamet, and they subsequently got married on October 2, 2016.
On October 31, 2017, Jonigkeit Starz drama Sweetbitter based on the novel of the same name. He is set to play Will the backwaiter assigned to train Tess and becomes her first friend; the series will premiere on May 6, 2018.
