His philanthropic efforts provide vital assistance to critical institutions and programs in a number of fields. Sarofim is a major contributor to the Houston Ballet and the Museum of Fine Arts, a favorite of his daughter Allison. He has provided support to Memorial Sloan–Kettering Cancer Center, the Texas Children’s Hospital and the University of Texas Health Science Center at Houston for construction of the $120 Million environment friendly, Fayez S. Sarofim Research Building. Sarofim also has made financial gifts to the Houston Grand Opera, the Houston Symphony, donating high seven figures to the Hobby Center for the Performing Arts, creating the 2600 seat, Sarofim Hall, designed for touring Broadway shows, the Alley Theatre, and the Los Angeles Opera.