Sampson has continued to have infrequent mainstream roles, most notably playing a Teacher in teen comedy Pretty Cool (2001). She began her career in the porn industry by doing several hardcore films in 1998 under the single-name aliases "Nicolette" and "Zoe," but quickly left this side of the industry to perform in softcore films. Her credits from this softcore period (2000–2003) include erotic TV shows such as Lady Chatterly's Stories, The Voyeur, Thrills, The Best Sex Ever and Bedtime Stories. She also performed in a number of feature-length softcore films (under the name Holly Sampson), and non-hardcore fetish videos (under her alias Nicolette Foster). In 2008, Sampson returned to the hardcore non-fetish side of adult film, under the name Holly Sampson.