Weston had countless character roles in major films such as The Cincinnati Kid and The Thomas Crown Affair. On television he made numerous appearances such as murderer Fred Calvert in the 1958 Perry Mason episode, "The Case of the Daring Decoy."
In the 1960–1961 television season, Weston appeared as Chick Adams, a reporter, on the CBS sitcom My Sister Eileen starring Shirley Bonne and Elaine Stritch as two sisters who share a New York City brownstone apartment. The other co-stars were Stubby Kaye, Rose Marie and Raymond Bailey.
The next season, 1961–1962, he starred in the short-lived sitcom The Hathaways (ABC, produced by Screen Gems), in which he and Peggy Cass adopted a trio of chimpanzees (the Marquis Chimps).
Weston, a Cleveland, Ohio native, usually played comic roles in films such as Cactus Flower (1969) and Please Don't Eat the Daisies (1960). He occasionally essayed heavier parts, such as the scheming crook and stalker who, along with Alan Arkin and Richard Crenna, attempts to terrorize and rob a blind Audrey Hepburn in the 1967 film Wait Until Dark. He also appeared as a guest star on The Fugitive series (1963).
Weston co-starred in Alan Alda's 1981 film The Four Seasons, and then reprised his role to star in a television series spinoff on CBS.
His second marriage was to Laurie Gilkes and lasted until his death from lymphoma on May 3, 1996, after a six-year struggle. He was 71 years old and also survived by his stepdaughter, Amy.
He also made guest appearances on such television series as Peter Gunn, Perry Mason, Rescue 8, The Twilight Zone (episodes "The Monsters Are Due on Maple Street", and "The Bard"), The Untouchables, Have Gun – Will Travel, Johnny Staccato, Thriller, The Lawless Years (2 episodes), Harrigan and Son, Stoney Burke, Breaking Point, The Fugitive, Bewitched, Gunsmoke, Twelve O'Clock High, Laredo, Tales of the Unexpected, The Man from U.N.C.L.E., The Carol Burnett Show, All in the Family and The George Burns and Gracie Allen Show.
