Returning from the war, Noble studied acting under Lee Strasberg and made appearances in Broadway theatre, and his television career started in soap operas, such as The Brighter Day, As the World Turns, The Doctors and A World Apart. His big screen roles included: Reverend John Witherspoon in the film version of the Broadway musical 1776 (1972); assorted roles as doctors in films such as One Summer Love (1976), 10 (1979) and Promises in the Dark (1979); Kaufman, the president's chief of staff, in Being There (1979); Father O'Flanagan in the comedy sequel Airplane II: The Sequel (1982); Sinclair in A Tiger's Tale (1987); Chief Wilkins in the comedy Paramedics (1988) and Dr. Bailey in Chances Are (1989).