While attending college, he was discovered at a bank by a casting agent who placed him in three high-profile commercials for Levi's 501 Jeans. He then moved to Los Angeles to pursue an acting and musical career. He played a bit role on Everyday Heroes. His film debut came in 1991 with the movie Shout, alongside John Travolta, Heather Graham, and Gwyneth Paltrow. Walters performed the song "Rockin' the Pad" on the Shout Soundtrack album.
Walters was engaged to Drew Barrymore in 1992. They broke up in 1993.
On September 20, 1994, Jamie released his self-titled debut album Jamie Walters. The first single from the album "Hold On" peaked at no. 16 on the Billboard Hot 100, and no. 76 in Australia. Jamie made appearances on MTV and various shows to promote the album, and also had a nationwide tour. The album sold over 1 million copies and was certified platinum.
In 1995, he said his favorite songs were American Girl by Tom Petty and Take the Money and Run by Steve Miller Band.
In 1997, Jamie released his second album 'Ride'. The album was certified gold. A third album, Believed, followed in 2002.
In 2002, Walters married Patty Walters. They met at Centinela Hospital, where they were both EMTs. He and Patty have 3 daughters, Ellie, Caiti, and Ana. In 2015 Patty filed for divorce.
With his residence in Los Angeles county, he pursued training, certification, and employment as a paramedic and worked with the Los Angeles County Fire Department. He is now working as a full-time firefighter/paramedic for the Los Angeles City Fire Department as of early 2004. Walters is focusing on his family and his career with the fire department but hopes to get back into music and acting sometime in the near Future.
In 2009, Walters appeared in the VH1 reality show Confessions of a Teen Idol, in which former teen idols attempt to resurrect their careers.
