Berlin's performance in the 1972 feature film The Heartbreak Kid which garnered her Golden Globe and Academy Award nominations for Best Supporting Actress. Additional screen credits during the 1970s included Getting Straight (1970), The Strawberry Statement (1970), Portnoy's Complaint (1971), and the leading role in Sheila Levine Is Dead and Living in New York (1975). She also had a leading role in "Old Fashioned Murder", a 1976 episode of Columbo. After an extended absence of several decades from acting in films, she has recently appeared in prominent works such as Margaret (2011), Inherent Vice (2014), and Café Society (2016). She received positive reviews for her performance as prosecutor Helen Weiss in the HBO miniseries The Night Of in 2016.
Berlin made her Broadway theatre debut in May's play After the Night and the Music in 2005. In 2012, she appeared in the play Other Desert Cities at the Mark Taper Forum in Los Angeles.
