He was a regular on the musical television series Fame for the show's final three seasons from 1984-1987. He appeared on Married... with Children as Bruno in the episode "Can't Dance, Don't Ask Me" (1989). He is well-remembered for his performance in the film Blood In Blood Out portraying the role of Cruz Candelaria.
Borrego appeared in productions at the Joseph Papp Theatre in New York City and the Mark Taper Forum in Los Angeles. In addition to performing on stage and in films such as Mi Vida Loca, Follow Me Home, New York Stories, and Con Air, he began Lupita Productions in 1990. He has produced theatrical productions and concerts as well as two 16mm short films: El Suendo de Simon [1] (1993) by James Borrego and Flattime (1995) by Jimmy Santiago Baca. He also played role of an original gangster on DarkRoom Familia's "Veteranos" in 1999. Borrego is a member of the theatre group "Tribal Players". He is well known for his recurring roles on the third season of 24 as Gael Ortega and the third season of Dexter as George King. In 2009, Borrego starred in the movie La Mission where he reunited with former Blood In Blood Out co-star Benjamin Bratt.
Borrego has also had his hand in directing. Borrego directed the no-budget indie film titled Closer to Bottom which premiered at the inaugural Austin Indie Fest in November, 2017. The movie won an award for Best Made in Texas Feature Film.
