Stafford's acting career started in 2000 when she was 15 years old after being spotted and cast in her first short movie for the Northern Media School. Stafford went on to perform in several theatre productions including Threepenny Opera and The Lion, The Witch and The Wardrobe.
Her other acting roles include starring as Cindi Marshall in Sky TV's Dream Team for two series from 2005 to 2007 and playing the role of the Jade Dragon escort in the 2005 film Moussaka & Chips.
Since 2006, Clement has starred in the BBC TV series The Real Hustle, a spin-off of the BBC drama series Hustle. Along with Alex Conran and Paul Wilson she demonstrates confidence and magic tricks, distraction scams and proposition bets on members of the public, to show viewers how to avoid being fooled by them. As of 2012, Clement has starred in all 106 episodes of all eleven series. She has also starred in all of the one-off specials: The 12 Scams Of Christmas, Winter Special, Worlds' Greatest Bar Bets, Best Ever Cons, Don't Miss A Trick and The Real Hustle Around the World.
In November 2008, Clement took part in the BBC Three show Celebrity Scissorhands in aid of Children in Need. In 2009 she appeared in Doghouse, a British zombie comedy, in which she played the leading character's girlfriend and the long-running British hospital drama Casualty, playing Jackie, a new member of the ambulance/paramedic crew.
Clement placed #54 in ZOO's hot 101 of 2009, #26 in Nuts' 100 Sexiest of 2009, #32 in the Top 100 ZOO's Beach Babe Awards 2011 and was #46 in FHM's 100 Sexiest Women of 2009.
Since 2010, Clement has been a spokesmodel for grooming product company Lynx, promoting their Lynx Rise range.
Also in November 2011, Clement presented the programme Skin Deep: The Business of Beauty, which was broadcast daily on BBC3 between 14 and 18 November 2011. In January 2012, she presented a BBC documentary titled Britain in Bed in which she revealed how British attitudes to sex have changed over the last 50 years. In 2013, she presented The Body Shocking Show alongside Pete Firman, which began on 14 March 2013.
At age 20 Clement suddenly lost hearing in her right ear. In 2012, she was fitted with a Phonak Lyric hearing device. Since then she has worked as a Celebrity ambassador for Phonak, helping to raise awareness of hearing loss.
On 17 February 2013, Clement married hairdresser Lee Stafford, whom she met whilst filming Celebrity Scissorhands. Jessica gave birth to their first child a son named Angel in June 2014. She gave birth to their second child a daughter named Elvis in January 2016. In April 2017 she gave birth to their third child, a girl named Sugar Mae.
2014 saw the release of horror film Devil's Tower, in which Stafford played Kate. She received positive reviews for her role, with Gareth Jones of Dread Central saying: "In the supporting realm, Stafford nearly steals the show as sexpot Kate, the gossipy neighbour whose delightful demeanour is the only thing that keeps her persistent nosiness from crossing the line. She’s note-perfect in the part from beginning to end".
In 2015, she appeared in the Channel 4 documentary show, The Auction House, with her husband, Lee Stafford.
In 2016, Stafford starred as Jasmine in comedy Gangsters, Gamblers and Geezers, a story about two lovable losers, Krish and Lee who get fired from their call centre jobs. 2016 also saw Stafford star in Redwood alongside Buffy star Nicholas Brandon, about a couple who go hiking in the woods and disturb a nest of vampires. Stafford finished off 2016 starring as Gillian alongside Alex Zane in Cannibals and Carpet Fitters, a comedy horror about a group of carpet fitters who are sent on a job to an old Country house in the middle of nowhere.
In 2017, Stafford filmed up and coming movies 'Order Of Kings: The Dark Kingdom' - a medieval fantasy drama, as well as horror movie 'Black Site' and dark comedy 'Dead Ringer'
