Joanne Kelly was born in Bay d'Espoir, Newfoundland. She studied at Acadia University. Her first movie role was the 2002 drama film The Bay of Love and Sorrows. She played alongside actors such as Paul Gross in Slings and Arrows and Gordon Pinsent in Heyday. From 2003 to 2004 she played Libby on the J. Michael Straczynski series Jeremiah on Showtime. She also played the role of Sara Collins in Fox's Vanished and the vampire Bianca in SciFi's The Dresden Files. She also appeared in the film Going the Distance.