He moved to Los Angeles and was hired by a doctor's office in North Hollywood, where he started to see a number of patients in 1978 who had a series of unusual conditions, including younger men with shingles, a case of Kaposi's sarcoma, and several patients who had symptoms of what appeared to be, but was not, lymphoma. In 1980, a series of patients came to a medical office he had opened in Sherman Oaks, all gay men who had a pattern of what appeared to be immune system disorders exhibited by significant loss of weight and swollen lymph nodes, accompanied by fever and rashes, in addition to two patients with chronic diarrhea, depressed white blood cell counts and fungal infections.