Manfrellotti got his first role in Flodder in Amerika! in 1992. Since then he has made several minor appearances in several mainstream shows. These include Law & Order, Seinfeld, Platypus Man, NYPD Blue and Mad Men. He has also appeared in several films including Grilled, Just My Luck, Welcome to Mooseport, Crime of the Century and Spy Hard.
His first major role was as Ray Barone's friend "Gianni" for 25 episodes on Everybody Loves Raymond and Doug Heffernan's friend "Gianni" in two episodes of The King of Queens. He enjoyed a recurring role on the comedy-drama Men of a Certain Age during its two-season run on TNT, appearing with Ray Romano— who created Everybody Loves Raymond with Writer Mike Royce.
