Ray is one of Chris Hardwick's co-hosts of The Nerdist Podcast and television show. In February 2011, Ray revealed on an episode of the podcast that "Jonah's Arcade", a video gaming-comedy pilot he created and stars in, was not picked up by Comedy Central. The pilot was later released on YouTube, produced by the same producers of Web Soup.
Ray recorded a seven-inch record of his stand-up comedy for AST Records entitled "This is Crazy Mixed-up Plumbing", released in 2006. He followed this up with his second release entitled "Hello, Mr. Magic Plane Person, Hello" on May 15, 2012, which received mixed reviews.
Ray hosts a weekly comedy show called The Meltdown with Kumail Nanjiani, produced by Nanjiani's wife, Emily Gordon, at Meltdown Comics in Los Angeles. In Late June 2013 Comedy Central announced a television production of the show titled The Meltdown with Jonah and Kumail, which debuted in July 2014.
On a 2014 episode of his podcast, Ray announced the launch of his own record label through ATS, Literally Figurative Records, a comedy/music label aimed to feature "a comic on one side and band they are friends with on the other."
On November 16, 2015, Mystery Science Theater 3000 creator Joel Hodgson announced plans for Ray to host the series' upcoming continuation. The series was funded through a successful Kickstarter campaign, and was released internationally by Netflix on April 14, 2017.
