Nathanson, who hails from Boston, was trained at Tufts University and graduated in 1995.
She began acting in 1996 with the TV movie Kiss & Tell. After, Nathanson has done several television series and television movies such as Beverly Hills, 90210 (1996-1997), Soldier of Fortune, Inc.. (1998-1999), The Zeta Project (2001-2003) and Spider-Man: The New Animated Series. Since 2004, she is also often heard in video games as voices of different characters.
In 2000, she wrote some episodes of the television series Just Deal, and there has also been nominated for an award held on to the Writers Guild of America Award in the category Best Screenplay for a Teen series.
