Lupe grew up in Denver, Colorado. Justine is a 2007 graduate of Denver School of the Arts theater program and 2011 graduate of the Juilliard School in New York City. Her grandmother, Kay Schomp, has a theater named after her at the Denver School of the Arts. Her father, John Lupe, is an exhibition specialist at the Denver Art Museum. Her mother, Katherine (Kiki) Schomp, has helped those less fortunate her entire career, as a social worker and Teacher.